various kinds of relationships Peridoksin Peridoksal With Oxidative carboxylation
In 1934 , George defines and separates vitamin B6 can heal scaly dermatitis in mice . Experiments chemical structure and synthesis of vitamin B6 or pirodoksin in charge in 1939 , along with other forms such as peridoksamin peridoksal phosphate as its active form in the set in the year 1945.
Vitamin B6 is found in three forms , namely : peridoksin , peridoksal and peridoksamin . Peridoksin hydrochloride is a synthetic form that is used as a drug . In the phosphorylated state , vitamin B6 serves as a coenzyme form of peridoksal phosphate ( PLP ) , peridoksamin phosphate ( PMP ) in a variety of transamination reactions , in addition to the PLP plays a role in various other reactions
A. DEFINITIONS
Peridoksil , peridoksal and peridoksamin are three forms of vitamin B6 found in nature . Vitamin B6 acts as a coenzyme form of peridoksal phosphate ( PLP ) and peridoksamin phosphate ( PMP ) in a variety of transamination reactions , in addition to the PLP plays a role in various other reactions .
Pirodoksil phosphate reactions participate in the metabolism of amino acids , such as transamination reaction , decarboxylation , and rasemasi . These reactions require enzymes was different , however, these enzymes require a coenzyme that is peridoksal phosphate .
B. ROLE B6 ( PERIDOKSIN , PERIDOKSAL ) in protein metabolism .
Vitamin B6 it contains important role in the biochemical processes which dimetabolisis food ingredients in the body . Pyribodoxine found in cells in an active form , known as Pyridoxal Phosphate ( PLP ) , a coenzyme in the metabolism of protein function . , Fats and carbohydrates . Unlike other vitamins are water soluble, the vitamin B6 does not have a direct role in energy metabolism .
Vitamin B6 plays a role in the phosphorylation form of PLP and PMP as a coenzyme in transamination especially , decarboxylation , and other reactions related to protein metabolism . PLP -dependent decarboxylation generate different forms of amines , such as epinephrine , and serotonin noreppinefrin . PLP also play a role in the formation of alpha - acid precursor heme in hemoglobin aminolevulinat.yaitu .
In addition , the PLP in the need for a change of tryptophan into niacin . As a coenzyme for phosphorylase , PLP helps release from the liver and muscle glycogen as glucose - 1 - phosphate . PLP is also involved in the change of linoleic acid to arachidonic acid that have important biological functions . Peridoksin are in high concentrations in the brain even at low plasma level . Brain disorders such as dementia may be caused by the lack of taking certain vitamins , especially vitamin B6 by the brain .
Because vitamin B6 plays a role in the metabolism of many proteins , kebutuhanya comparable to the protein needs . Sources of vitamin B6 are meats , poultry , yeast , cereals , Ubu and sweet potatoes . Vitamin B6 deficiency cause symptoms associated with impaired metabolism of proteins , such as weakness , irritability , and difficulty sleeping . Disadvantages further cause growth retardation , impaired motor function and convulsions , anemia , decreased antibody formation , peredangan tongue and sores on the lips , the corners of the mouth and kulit.kekurangan vitamin B6 can cause severe damage to the central nervous system .
C. RELATIONSHIP WITH oxidative carboxylation
DEKARBOLSILASI OKSIDATIFatau abbreviated as DO is the process of conversion of pyruvate to Asetilkoezim - A
Ø The process of Deyang where this process takes place Oxidative carboxylation is in the outer membrane as the phase between the mitocondria before the Krebs Cycle ( Krebs Cycle Pre ) so DO often incorporated directly in the Krebs Cycle .
Ø pyruvate oxidation reaction is the result of glycolysis into acetyl coenzyme - A , an important reaction step liaison between glycolysis pathways circumference tricarboxylic acid ( Krebs cycle ) .
Ø diaktalisis reaction by pyruvate dehydrogenase complex in the mitochondrial matrix involves three kinds of enzymes ( pyruvate dehydrogenase , dihidrolipoil transacetylase , and dihidrolipoil dehydrogenase ) , five kinds of coenzyme ( tiaminpirofosfat , lipoic acid , coenzyme - A , flavin adenine dinucleotide , and nicotinamide adenine dinucleotide ) and reaction takes place in five stages .
Ø Overall decarboxylation reaction is irreversible , with Δ G 0 = - 80 kcal per mole .
Ø This reaction is the main entrance of carbohydrates into the Krebs cycle .
Ø The first stage of the reaction catalyzed by pyruvate dehydrogenase which uses thiamine pyrophosphate as koenzimnya .
Ø decarboxylation of pyruvate produces α - hydroxyethyl compounds related to the group of the thiazole ring of thiamine pyrophosphate .
Ø In the second reaction step α - hydroxyethyl didehidrogenase into acetyl thiamine pyrophosphate was then transferred from the S atom to the next of the coenzyme , lipoic acid , which is bound to the enzyme transacetylase dihidrolipoil .
Ø In this case the disulfide group of lipoic acid is converted to the form of its reduction , sulfhydryl groups . In the third stage of the reaction , the acetyl group was transferred to the intermediate enzyme of the acidic group lipoil dihidrolipoat , kegugus thiol ( sulfhydryl on coenzyme - A ) .
Ø Then acetyl co - enzyme A release from the pyruvate dehydrogenase complex .
Ø In the fourth reaction step lipoil thiol groups on cluster -bound transacetylase dihidrolipoil oxidized back into shape disulfidanya with dihidrolipoil dehydrogenase enzyme that binds to FAD ( flavin adenine dinucleotide ) .
Ø Finally ( fifth reaction stage ) + FADH ( reduced form of FAD ), which remains bound to the enzyme , oxidized back to NAD + ( nicotinamide adenine dinucleotide ) widened FAD , while NAD + is transformed into NADH ( reduced form of NAD + ) .
REFERENCES
The basic principle of the science of nutrition , Sunita Almatsier
http://obtrando.wordpress.com/glo-vitamin-b6/
http://www.VIT.B6.com/index.php?option=com_content&task=category§ionid=18&id=34&Ite
In 1934 , George defines and separates vitamin B6 can heal scaly dermatitis in mice . Experiments chemical structure and synthesis of vitamin B6 or pirodoksin in charge in 1939 , along with other forms such as peridoksamin peridoksal phosphate as its active form in the set in the year 1945.
Vitamin B6 is found in three forms , namely : peridoksin , peridoksal and peridoksamin . Peridoksin hydrochloride is a synthetic form that is used as a drug . In the phosphorylated state , vitamin B6 serves as a coenzyme form of peridoksal phosphate ( PLP ) , peridoksamin phosphate ( PMP ) in a variety of transamination reactions , in addition to the PLP plays a role in various other reactions
A. DEFINITIONS
Peridoksil , peridoksal and peridoksamin are three forms of vitamin B6 found in nature . Vitamin B6 acts as a coenzyme form of peridoksal phosphate ( PLP ) and peridoksamin phosphate ( PMP ) in a variety of transamination reactions , in addition to the PLP plays a role in various other reactions .
Pirodoksil phosphate reactions participate in the metabolism of amino acids , such as transamination reaction , decarboxylation , and rasemasi . These reactions require enzymes was different , however, these enzymes require a coenzyme that is peridoksal phosphate .
B. ROLE B6 ( PERIDOKSIN , PERIDOKSAL ) in protein metabolism .
Vitamin B6 it contains important role in the biochemical processes which dimetabolisis food ingredients in the body . Pyribodoxine found in cells in an active form , known as Pyridoxal Phosphate ( PLP ) , a coenzyme in the metabolism of protein function . , Fats and carbohydrates . Unlike other vitamins are water soluble, the vitamin B6 does not have a direct role in energy metabolism .
Vitamin B6 plays a role in the phosphorylation form of PLP and PMP as a coenzyme in transamination especially , decarboxylation , and other reactions related to protein metabolism . PLP -dependent decarboxylation generate different forms of amines , such as epinephrine , and serotonin noreppinefrin . PLP also play a role in the formation of alpha - acid precursor heme in hemoglobin aminolevulinat.yaitu .
In addition , the PLP in the need for a change of tryptophan into niacin . As a coenzyme for phosphorylase , PLP helps release from the liver and muscle glycogen as glucose - 1 - phosphate . PLP is also involved in the change of linoleic acid to arachidonic acid that have important biological functions . Peridoksin are in high concentrations in the brain even at low plasma level . Brain disorders such as dementia may be caused by the lack of taking certain vitamins , especially vitamin B6 by the brain .
Because vitamin B6 plays a role in the metabolism of many proteins , kebutuhanya comparable to the protein needs . Sources of vitamin B6 are meats , poultry , yeast , cereals , Ubu and sweet potatoes . Vitamin B6 deficiency cause symptoms associated with impaired metabolism of proteins , such as weakness , irritability , and difficulty sleeping . Disadvantages further cause growth retardation , impaired motor function and convulsions , anemia , decreased antibody formation , peredangan tongue and sores on the lips , the corners of the mouth and kulit.kekurangan vitamin B6 can cause severe damage to the central nervous system .
C. RELATIONSHIP WITH oxidative carboxylation
DEKARBOLSILASI OKSIDATIFatau abbreviated as DO is the process of conversion of pyruvate to Asetilkoezim - A
Ø The process of Deyang where this process takes place Oxidative carboxylation is in the outer membrane as the phase between the mitocondria before the Krebs Cycle ( Krebs Cycle Pre ) so DO often incorporated directly in the Krebs Cycle .
Ø pyruvate oxidation reaction is the result of glycolysis into acetyl coenzyme - A , an important reaction step liaison between glycolysis pathways circumference tricarboxylic acid ( Krebs cycle ) .
Ø diaktalisis reaction by pyruvate dehydrogenase complex in the mitochondrial matrix involves three kinds of enzymes ( pyruvate dehydrogenase , dihidrolipoil transacetylase , and dihidrolipoil dehydrogenase ) , five kinds of coenzyme ( tiaminpirofosfat , lipoic acid , coenzyme - A , flavin adenine dinucleotide , and nicotinamide adenine dinucleotide ) and reaction takes place in five stages .
Ø Overall decarboxylation reaction is irreversible , with Δ G 0 = - 80 kcal per mole .
Ø This reaction is the main entrance of carbohydrates into the Krebs cycle .
Ø The first stage of the reaction catalyzed by pyruvate dehydrogenase which uses thiamine pyrophosphate as koenzimnya .
Ø decarboxylation of pyruvate produces α - hydroxyethyl compounds related to the group of the thiazole ring of thiamine pyrophosphate .
Ø In the second reaction step α - hydroxyethyl didehidrogenase into acetyl thiamine pyrophosphate was then transferred from the S atom to the next of the coenzyme , lipoic acid , which is bound to the enzyme transacetylase dihidrolipoil .
Ø In this case the disulfide group of lipoic acid is converted to the form of its reduction , sulfhydryl groups . In the third stage of the reaction , the acetyl group was transferred to the intermediate enzyme of the acidic group lipoil dihidrolipoat , kegugus thiol ( sulfhydryl on coenzyme - A ) .
Ø Then acetyl co - enzyme A release from the pyruvate dehydrogenase complex .
Ø In the fourth reaction step lipoil thiol groups on cluster -bound transacetylase dihidrolipoil oxidized back into shape disulfidanya with dihidrolipoil dehydrogenase enzyme that binds to FAD ( flavin adenine dinucleotide ) .
Ø Finally ( fifth reaction stage ) + FADH ( reduced form of FAD ), which remains bound to the enzyme , oxidized back to NAD + ( nicotinamide adenine dinucleotide ) widened FAD , while NAD + is transformed into NADH ( reduced form of NAD + ) .
REFERENCES
The basic principle of the science of nutrition , Sunita Almatsier
http://obtrando.wordpress.com/glo-vitamin-b6/
http://www.VIT.B6.com/index.php?option=com_content&task=category§ionid=18&id=34&Ite
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