Hemoglobin
in the blood carries oxygen from the lungs to all body tissues and
bring back carbon dioxide from whole cells to the lungs and expelled
from the body . Myoglobin acts as a reservoir of oxygen : accept , store and release oxygen in muscle cells . A total of approximately 80 % iron in the body is in hemoglobin ( Sunita , 2001) .
According to MOH as for hemoglobin , among others :
Regulate the exchange of oxygen with carbon dioxide in the body tissues .
Take oxygen from the lungs and then carried to all tissues of the body to be used as fuel .
Brings carbon dioxide from the tissues of the body as a result of metabolism to the lungs to waste, to determine whether a person is deprived of blood or not , can be determined by measuring hemoglobin levels . The decrease in mean hemoglobin levels of normal blood deficiency called anemia ( Widayanti , 2008) .
Structure of Hemoglobin ( Hb )
At the center of the molecule consisting of a heterocyclic ring , known as porphyrins that hold one atom of iron , the iron atom is the site / local bonding of oxygen . Iron -containing porphyrin called heme . The name is a combination of hemoglobin heme and globin , the globin as a generic term for globular proteins . There are several proteins containing heme and hemoglobin are the most well known and widely studied .
In adult humans , hemoglobin is a tetramer ( containing 4 submit a protein ) , which consists of two of each of the alpha and beta subunits are non- covalently bound . Sub- units are structurally similar and similarly sized . Each subunit has a molecular weight of approximately 16,000 Dalton , so that the total molecular weight of 64,000 Dalton tetramernya be . Each subunit of hemoglobin contains one heme , so the overall capacity of hemoglobin has four oxygen molecules ( Wikipedia , 2007) .
According to MOH as for hemoglobin , among others :
Regulate the exchange of oxygen with carbon dioxide in the body tissues .
Take oxygen from the lungs and then carried to all tissues of the body to be used as fuel .
Brings carbon dioxide from the tissues of the body as a result of metabolism to the lungs to waste, to determine whether a person is deprived of blood or not , can be determined by measuring hemoglobin levels . The decrease in mean hemoglobin levels of normal blood deficiency called anemia ( Widayanti , 2008) .
Structure of Hemoglobin ( Hb )
At the center of the molecule consisting of a heterocyclic ring , known as porphyrins that hold one atom of iron , the iron atom is the site / local bonding of oxygen . Iron -containing porphyrin called heme . The name is a combination of hemoglobin heme and globin , the globin as a generic term for globular proteins . There are several proteins containing heme and hemoglobin are the most well known and widely studied .
In adult humans , hemoglobin is a tetramer ( containing 4 submit a protein ) , which consists of two of each of the alpha and beta subunits are non- covalently bound . Sub- units are structurally similar and similarly sized . Each subunit has a molecular weight of approximately 16,000 Dalton , so that the total molecular weight of 64,000 Dalton tetramernya be . Each subunit of hemoglobin contains one heme , so the overall capacity of hemoglobin has four oxygen molecules ( Wikipedia , 2007) .
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